PRODUCT DETAILS

About Bpace H 2.5 mg/12.5 mg Tablet

HYDROCHLOROTHIAZIDE+RAMIPRIL belongs to a class of medication called 'anti-hypertensive agents' prescribed alone or in combination with other drugs to lower raised blood pressure. Hypertension (High blood pressure) is a condition in which the force exerted by the blood against the artery walls becomes so high that it causes health problems, such as heart disease.

HYDROCHLOROTHIAZIDE+RAMIPRIL contains two medicines, namely: Ramipril (blood pressure-lowering agent) and Hydrochlorothiazide (diuretics or water pills). Ramipril is an angiotensin-converting enzyme or ACE inhibitor that lower increased blood pressure by blocking a naturally occurring substance known as angiotensin II (that tightens your blood vessels). It allows these constricted blood vessels to relax and therefore helps lower high blood pressure. On the other hand, Hydrochlorothiazide (diuretic) works by increasing the amount of urine passed out from the kidneys. It effectively reduces excess fluid overload in the body and treats edema (swelling) associated with heart, liver, kidney, or lung disease. This reduces the heart's workload and makes the heart more efficient at pumping blood throughout the body. Thus, collectively, both help lower high blood pressure, reducing heart attack, or stroke chances. 

You can take HYDROCHLOROTHIAZIDE+RAMIPRIL with a meal or after/before a meal. Your doctor will advise you on the exact dosage and how often you have to take HYDROCHLOROTHIAZIDE+RAMIPRIL based on your medical condition. In some cases, you may experience headaches, feeling tired, slow heart rate, and nausea. Most of these side effects of HYDROCHLOROTHIAZIDE+RAMIPRIL do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor. HYDROCHLOROTHIAZIDE+RAMIPRIL may lower your blood pressure, especially if taken with alcohol. So, avoid driving and operating heavy machinery.

Try not to stop taking this medicine of your own. Even if your blood pressure becomes normal, you should not stop using HYDROCHLOROTHIAZIDE+RAMIPRIL. Doing so may worsen your condition. Let your doctor know if you have had or currently have any liver, kidney, or heart problems. In pregnancy and lactation, HYDROCHLOROTHIAZIDE+RAMIPRIL should only be taken after consulting your doctor. You should regularly monitor your blood pressure and heart rate. Please tell your doctor if you are taking any other medicines or are allergic to HYDROCHLOROTHIAZIDE+RAMIPRIL. Reducing the amount of table salt (sodium chloride) in your food often relieves the body's swelling.

Uses of Bpace H 2.5 mg/12.5 mg Tablet

Hypertension (high blood pressure)

Medicinal Benefits of Bpace H 2.5 mg/12.5 mg Tablet

HYDROCHLOROTHIAZIDE+RAMIPRIL contains Ramipril and hydrochlorothiazide. Ramipril is an angiotensin-converting enzyme (ACE) inhibitor that lowers increased blood pressure by blocking a naturally occurring substance known as angiotensin II (that tightens your blood vessels). It allows these constricted blood vessels to relax and therefore helps lower high blood pressure. On the other hand, Hydrochlorothiazide (diuretic) works by increasing the amount of urine passed out from the kidneys. It effectively reduces excess fluid levels in the body and treats edema (swelling) associated with heart, liver, kidney, or lung disease. This reduces the heart's workload and makes the heart more efficient at pumping blood throughout the body. Thus, collectively, both help lower high blood pressure, reducing the chances of heart attack or stroke. However, HYDROCHLOROTHIAZIDE+RAMIPRIL does not cure high blood pressure (hypertension) but does help control it. In addition to this, HYDROCHLOROTHIAZIDE+RAMIPRIL also reduces the physical effects of anxiety. 

Directions for Use

HYDROCHLOROTHIAZIDE+RAMIPRIL can be taken orally with or without food or as directed by your doctor. It is best to avoid taking this medication within 4 hours of your bedtime to prevent having to get up to urinate. Dosage is based on your medical condition, age, and response to treatment. If you are taking other medications to lower your cholesterol (like cholestyramine), try to take HYDROCHLOROTHIAZIDE+RAMIPRIL at least 4 hours before or at least 4 to 6 hours after taking cholestyramine.

Side Effects of Bpace H 2.5 mg/12.5 mg Tablet

Most of the side effects of HYDROCHLOROTHIAZIDE+RAMIPRIL do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor. The most common side effects of HYDROCHLOROTHIAZIDE+RAMIPRIL are dizziness, vision blurred, weakness, and nausea (feeling sick). Very rarely, it can cause low blood pressure, and difficulty breathing. It is not necessary for everyone to experience the above side effects. In case of any discomfort, speak with your doctor.

Similar Drugs

For informational purposes only. Consult a doctor before taking any medicines.

In-Depth Precautions and Warning

Drug Warnings

HYDROCHLOROTHIAZIDE+RAMIPRIL should not be given to people allergic to HYDROCHLOROTHIAZIDE+RAMIPRIL, who have low blood pressure (less than 90 mm of Hg), have had a heart attack, diabetes, kidney disease, liver disease, pregnant women, or planning to get pregnant and breastfeeding women. HYDROCHLOROTHIAZIDE+RAMIPRIL may alter your blood sugar level, so tell your doctor about this before using HYDROCHLOROTHIAZIDE+RAMIPRIL. Besides this, it is contraindicated in low blood pressure (hypotension), cardiogenic shock (sudden stopping of blood flow to the heart), anuria (patients with nil urine output), and aortic stenosis (heart valve problem). HYDROCHLOROTHIAZIDE+RAMIPRIL can pass into breast milk, but its effect on the baby is not known. So, it is better to tell your doctor if you are taking HYDROCHLOROTHIAZIDE+RAMIPRIL and breastfeeding. Do not consume alcohol with HYDROCHLOROTHIAZIDE+RAMIPRIL as it may increase the risk of low blood pressure. Avoid potassium supplements with HYDROCHLOROTHIAZIDE+RAMIPRIL as it may lead to high potassium levels in the blood. Regular blood tests and blood pressure monitoring are recommended while taking HYDROCHLOROTHIAZIDE+RAMIPRIL. Drink a lot of fluids as HYDROCHLOROTHIAZIDE+RAMIPRIL can cause dehydration, so to avoid unpleasant side effects, increase the intake of fluids. HYDROCHLOROTHIAZIDE+RAMIPRIL can make your skin sensitive to sunlight try to cover the skin with a cloth or wear sunscreen lotion (SPF) whenever going outdoor. 

Drug Interactions

Drug-Drug Interaction:

HYDROCHLOROTHIAZIDE+RAMIPRIL may interact with other diuretics, blood pressure-lowering drugs (aliskiren, metoprolol, sacubitril, sacuatorvastatin), anti-epilepsy medicines (carbamazepine, phenobarbital), anti-depression medicines (lithium), immune-suppressing drugs (cyclosporine), anti-diabetic drugs (metformin) and painkillers (ibuprofen, aspirin), anti-gout drugs (allopurinol), pain killers (diclofenac, ibuprofen), potassium supplements, birth control pills (drospirenone),  immune system affecting drugs (everolimus, sirolimus), etc. If you are taking any of the above, speak with your doctor.

Drug-Disease Interaction:

HYDROCHLOROTHIAZIDE+RAMIPRIL should not be given to people with cardiogenic shock (when the heart fails to pump required blood to the body), heart valve problem (stenosis), low blood pressure (hypotension), coronary heart disease, liver disease, or heart failure, gout, sensitive skin to sunlight, low serum potassium (hypokalemia), patients with nil urine output (anuria), etc.

Safety Advice

ALCOHOL

HYDROCHLOROTHIAZIDE+RAMIPRIL may enhance the hypotensive (low blood pressure) effect if alcohol is taken along with it. For better advice, you should consult your doctor about whether you can take HYDROCHLOROTHIAZIDE+RAMIPRIL with alcohol.

PREGNANCY

The use of HYDROCHLOROTHIAZIDE+RAMIPRIL or any ACE inhibitors (Ramipril) is usually contraindicated during the second and third trimester of pregnancy. It may cause harm to the developing fetus. Hence, you should always consult your doctor before using HYDROCHLOROTHIAZIDE+RAMIPRIL.

BREAST FEEDING

Use of HYDROCHLOROTHIAZIDE+RAMIPRIL is not recommended during the breastfeeding stage.

DRIVING

Drive with caution, HYDROCHLOROTHIAZIDE+RAMIPRIL may cause blurry vision, and dizziness or weariness may occur.

LIVER

Rare elevation in the liver enzymes (like bilirubin) has been observed while taking HYDROCHLOROTHIAZIDE+RAMIPRIL, so it must be taken with caution. If you have a history of liver diseases/conditions, the dose may have to be adjusted by your doctor.

KIDNEY

HYDROCHLOROTHIAZIDE+RAMIPRIL is to be taken with caution, especially in case of severe kidney disease. The dose may have to be adjusted by your doctor. HYDROCHLOROTHIAZIDE+RAMIPRIL should be given with precaution in hemodialysis conditions.